Rapid Uptake and Photodynamic Inactivation of Staphylococci by Ga(III)-Protoporphyrin IX
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چکیده
منابع مشابه
Uptake of protoporphyrin IX by isolated rat liver mitochondria.
Rat liver mitochondria accumulate protoporphyrin IX from the suspending medium into the inner membrane in parallel with the magnitude of the transmembrane K+ gradient (K+in/K+out). Only protoporphyrin IX taken up in parallel with the transmembrane K+ gradient is available for haem synthesis. Coproporphyrins (isomers I and III) are not taken up by the mitochondria. The results support the sugges...
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BACKGROUND Dermatophytes are filamentous keratinophilic fungi. Trichophyton rubrum is a prevalent infectious agent in tineas and other skin diseases. Drug therapy is considered to be limited in the treatment of such infections, mainly due to low accessibility of the drug to the tissue attacked and development of antifungal resistance in these microorganisms. In this context, Photodynamic Therap...
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BACKGROUND Hypericin (HYP) is a naturally occurring photosensitizer. Cellular uptake and photodynamic inactivation after incubation with this photosensitizer have neither been examined in medulloblastoma cells in vitro, nor compared with 5-aminolevulinic acid-derived protoporphyrin IX (5-ALA-derived PpIX). METHODS In 3 medulloblastoma cell lines (D283 Med, Daoy, and D341 Med) the time- and co...
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v Apoptosis can be induced in several cell lines by photodynamic treatment with different photosensitizers including aminolevulinic acid (ALA)-stimulated endogenous protoporphyrin IX (PpIX). This PpIX is successfully used as tumor marker in diagnosis, and owns good sensitizing properties for tumor therapy (PDT). The aim of the study was to investigate cell death mechanisms and its consequences ...
متن کاملIntralesional photodynamic therapy: a comment on 'Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy' by Gerritsen et al.
application in photodynamic therapy (PDT). The authors did not mention intralesional PDT, a seldom used technique which potential, though, is in our opinion underrecognized and underestimated. As shown in table 1 , intralesional PDT has been reported to be an effective and safe treatment for skin metastases of breast cancer [2] , superficial and nodular basal-cell carcinoma [3, 4, 6, 7] , squam...
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ژورنال
عنوان ژورنال: ACS Infectious Diseases
سال: 2018
ISSN: 2373-8227,2373-8227
DOI: 10.1021/acsinfecdis.8b00125